ATV399
CAS No. : 393834-37-2
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| Cat. No. : | HY-119119 |
| M.Wt: | 465.52 |
| Formula: | C24H23N3O5S |
| Purity: | >98 % |
| Solubility: |
ATV399 is an inducible nitric oxide synthase (iNOS) inhibitor. ATV399 reduces NO production via allosteric inhibition of iNOS dimerization, thereby protecting rat pancreatic islet β-cells from cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 can be used in research related to type 1 diabetes[1]. In Vitro:ATV399 (0.04-5 μM; 48 h) inhibits the activation of cytokine-induced active caspase-9 with an IC50 of 3.3 μM. Meanwhile, in rat insulin-secreting INS1E cells treated with pro-inflammatory cytokines and high glucose, this compound fully preserves cell viability, protects insulin secretion function, and reduces endoplasmic reticulum stress levels and the expression of pro-apoptotic proteins[1].
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