MRL20
CAS No. : 393794-32-6
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| Cat. No. : | HY-122222 |
| M.Wt: | 527.49 |
| Formula: | C28H24F3NO6 |
| Purity: | >98 % |
| Solubility: |
MRL20 is a PPARγ constitutive and allosteric agonist. MRL20 enhances the interaction between PPARγ and the co-activating peptide of TRAP220, with its EC50 being 10 nM. Even after being covalently blocked in the constitutive pocket by GW9662 (HY-16578) or T0070907 (HY-13202), MRL20 can still strengthen the interaction between PPARγ and TRAP220, with EC50 values of 176 and 440 nM respectively. MRL20 fails to completely inhibit its cell activation effect. MRL20 can be used to study the allosteric regulatory mechanism of PPARγ[1].
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