Imidazolidinyl urea

Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by MRGPRX2 activation of mast cells^[1][2][3]. In Vitro:Imidazolidinyl urea (50-200 μg/mL; 0-120 seconds) activates calcium mobilization, increases intracellular calcium ion concentration, and induces the release of inflammatory mediators in LAD2 cells^[1].
Imidazolidinyl urea (50-200 μg/mL; 0-120 seconds) activates calcium mobilization in HEK293 cells expressing MRGPRX2, but has no significant effect in negative control HEK293 cells^[1]. In Vivo:Imidazolidinyl urea (apply topically on the back skin; 100-300 μg/mL; 1-3 days) can induce contact dermatitis in mice^[1].