Indole-3-pyruvic acid
CAS No. : 392-12-1
| Size | Price | Stock |
|---|---|---|
| 100mg | $36 | In-stock |
| 250mg | $60 | In-stock |
| 1g | $150 | In-stock |
| 5g | $497 | In-stock |
| 10g | $960 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-W028393 |
| M.Wt: | 203.20 |
| Formula: | C11H9NO3 |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;H2O : 20 mg/mL (ultrasonic;adjust pH to 12 with NaOH);DMSO : 166.67 mg/mL (ultrasonic) |
Indole-3-pyruvic acid, a keto analogue of tryptophan, is an orally active AHR agonist. Indole-3-pyruvic acid has antioxidant properties, and can be used in the research of inflammation, anxiety[1][2][3].
IC50 & Target:AHR[1]
In Vitro:Indole-3-pyruvic acid (50 and 250 μM, 24 h) activates AHR in HepG2 cells[1].
Indole-3-pyruvic acid (50 μM, 4 days) does not inhibit Th1 cell differentiation but promotes Tr1 differentiation[1].
Indole-3-pyruvic acid (1 mM, 24 h) reduces UVB-induced cytotoxicity in HaCaT cells[1].
Indole-3-pyruvic acid (25 mM, 6 h) reduces the levels of COX-2 in HaCaT cells[2].
In Vivo:Indole-3-pyruvic acid (oral administration, fed in MF chow (0.1%) for 5 d) activates AHR in BALB/c mice[1].
Indole-3-pyruvic acid (oral administration, fed in MF chow (0.1%) for 5 wk) abrogates chronic inflammation in a T cell-mediated colitis model[1].
Indole-3-pyruvic acid (100 μM, dose at skin) protects against UVB-induced skin damage in HR-1 hairless mice[2].
Indole-3-pyruvic acid (intraperitoneal injection, 100-200 mg/kg) increases the time spent in the open arms of the elevated plus maze in mice[3].
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