trans-2-Decenal

trans-2-Decenal ((E)-Dec-2-enal) acts as a urease inhibitor and antibacterial agent against Helicobacter pylori, with an IC₅₀ of 9.484 μg/mL against Helicobacter pylori urease. trans-2-Decenal reduces the urease activity of Helicobacter pylori, and possesses antibacterial, bactericidal, anti-biofilm and anti-migratory activities. It alters the morphology of Helicobacter pylori, induces bacterial rupture, inhibits biofilm formation, reduces the number of mature biofilms and impairs the migratory capacity of Helicobacter pylori. trans-2-Decenal disrupts the cell wall integrity of Phytophthora capsici, damages membrane integrity and permeability, triggers intracellular reactive oxygen species (ROS) accumulation, decreases glutathione levels and disrupts the mitochondrial membrane potential of Phytophthora capsici. trans-2-Decenal is applicable to studies related to Helicobacter pylori and plant diseases induced by and Phytophthora capsici^[2]. In Vitro:trans-2-Decenal (4-512 μg/mL; 3-5 d) exhibits in vitro bacteriostatic and bactericidal activities against clinically drug-resistant strains of Helicobacter pylori (C907, C101, R1, R2, R4, R10, R16, R24, R36, R40) and the standard strain ATCC43504, with MIC values ranging from 8 to 16 μg/mL and MBC values ranging from 16 to 32 μg/mL^[1].
trans-2-Decenal (4-16 μg/mL; 72 h) inhibits the growth of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner within 72 h, with complete growth inhibition achieved at 16 μg/mL^[1].
trans-2-Decenal (16-64 μg/mL; 24 h) exhibits rapid, concentration-dependent bactericidal activity against the standard Helicobacter pylori strain ATCC43504: 16 μg/mL eliminates all viable bacteria within 4 h, while complete bactericidal effect is achieved within 1 h at 32 μg/mL or 64 μg/mL^[1].
trans-2-Decenal (16 μg/mL; 4 h) alters the morphology of the standard Helicobacter pylori strain ATCC43504 and causes damage to its ultrastructure after 4 h of incubation^[1].
trans-2-Decenal (8-64 μg/mL; 1-3 d) inhibits biofilm formation and mature biofilm growth of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner, with the maximum inhibitory effect achieved at 16 μg/mL^[1].
trans-2-Decenal (0-16 μg/mL; 20 min) inhibits Helicobacter pylori urease activity in a concentration-dependent manner, with an IC₅₀ of 9.484 μg/mL^[1].
trans-2-Decenal (4-32 μg/mL; 4 d) inhibits the migration ability of the standard Helicobacter pylori strain ATCC43504 in a concentration-dependent manner, and complete growth inhibition is observed at the concentration of 32 μg/mL^[1].
Trans-2-decenal (16-32 μg/mL; 12-48 h) induces dose-dependent intracellular ROS accumulation and depletes glutathione levels in Phytophthora capsici strain LT263: a strong DCFH-DA fluorescence signal is detected at the concentration of 32 μg/mL after 12 h of treatment; after 48 h of treatment, the GSH content decreases to 44.39% of that in the control group at the concentration of 32 μg/mL^[2].
Trans-2-decenal (16-32 μg/mL; 12 h) dose-dependently disrupts the mitochondrial membrane potential of Phytophthora capsici strain LT263^[2].