NSC 185058
CAS No. : 39122-38-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $75 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $750 | In-stock |
| 100mg | $1050 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-125169 |
| M.Wt: | 215.27 |
| Formula: | C11H9N3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. Inhibition of ATG4B using NSC 185058 markedly attenuates autophagic activity[1].
IC50 & Target: ATG4B[1]
Autophagy[1]
In Vivo: NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].
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