PD318088
CAS No. : 391210-00-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $134 | In-stock |
| 10mg | $206 | In-stock |
| 25mg | $433 | In-stock |
| 50mg | $654 | In-stock |
| 100mg | $988 | In-stock |
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| Cat. No. : | HY-12062 |
| M.Wt: | 561.09 |
| Formula: | C16H13BrF3IN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295). PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088 can be used for cancer research[1]. IC50 & Target: MEK[1][2] In Vitro: PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. Formation of the ternary complexes with PD318088 and MgATP results in moderate increases (to 140 nM) for the Kd monomer-dimer for both MEK1 and MEK2. The binding of PD318088 and MgATP to MEK1 also abolishes the formation of tetramers and higher-order aggregates[1].The mechanism of inhibition for PD318088 is probably a result of localized conformational changes in the active site and not a global change in the overall structure[1].
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