Difludiazepam
CAS No. : 39080-67-6
(Synonyms: Ro 07-4065)
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| Cat. No. : | HY-124467 |
| M.Wt: | 320.72 |
| Formula: | C16H11ClF2N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Difludiazepam, a benzodiazepine derivative, is a GABAA receptor ligand with an IC50 of 4.1 nM. Difludiazepam binds to an allosteric site on the GABAA receptor to potentiate the receptor's response to GABA, reducing neuron excitability. Difludiazepam contains halogenated groups at the ortho position of its phenyl ring[1][2]. IC50 & Target:GABAA Receptor[1] In Vitro:Difludiazepam exhibits a predicted GABAA receptor binding affinity (log 1/c = 9.16) that is greater than the previously reported highest predicted binding affinity for designer benzodiazepines[1].
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