RHPS4
CAS No. : 390362-78-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 50mg | $290 | In-stock |
| 100mg | $490 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-101089 |
| M.Wt: | 458.48 |
| Formula: | C23H20F2N2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
RHPS4 is a potent telomerase inhibitor (IC50 = 0.33 μM). RHPS4 is a DNA damage inducer[1][2].
IC50 & Target: IC50: 0.33 μM (telomerase in the TRAP assay)[1].
In Vitro: RHPS4 could sensitize tumor cells to anticancer agents that act via disparate mechanisms[1].
RHPS4 (0.5-1 μM, 15 days) induces a senescent-like growth arrest in MCF-7 cells[1].
RHPS4 (1 μM, 4 days) induces phosphorylation of H2AX in transformed and tumor cells[2].
In Vivo: RHPS4 (15 mg/kg, iv, 15 days) treatment produces a marked inhibition of tumor weight (tumor weight inhibition [TWI] about 80%; P < 0.001) in a very short time, and this effect persists for at least 30 days. A complete tumor response is observed in 80% of mice, and 40% are cured[2].
In all the other tumor xenografts, RHPS4 treatment produces about 50% (P < 0.001) TWI at the nadir of the effect and, more important, results in a delay of tumor growth of about 15 (M14 and PC3) and 10 (HT29 and H460) days[2].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- RHPS4
- Cat. No.:
- HY-101089
- Quantity:
Your information is safe with us.