Trioxsalen
CAS No. : 3902-71-4
(Synonyms: Trisoralen; Trioxysalen; TMP)
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| 500mg | $180 | In-stock |
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| Cat. No. : | HY-B1157 |
| M.Wt: | 228.25 |
| Formula: | C14H12O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 2 mg/mL (ultrasonic);H2O : 1 mg/mL (ultrasonic;warming;heat to 80°C) |
Trioxsalen (Trisoralen), a psoralen derivative, is a photochemical DNA crosslinker. Trioxsalen only works after photoactivation with near ultraviolet light. Trioxsalen is a photosensitizer that can be used for the research of vitiligo and hand eczema. Trioxsalen is used for visualization of genomic interstrand cross-links localized by laser photoactivation[1][2][3].
In Vitro: Trioxsalen (200 nM) plus 365 nm light produce DNA crosslinks but not breaks in mouse L1210 leukemia cells[4].
Trioxsalen/UVA treatment of HaCaT keratinocytes induces NF-kappaB binding activity, and that this is a synergistic effect[5].
Trioxsalen shows anti-inflammatory capacities in vitro[5].
In Vivo: Trioxsalen induces dose-dependent depletion of ATPase-positive LCs, with a maximal depletion of 80%, in oral mucous membrane (OMM) with PUVA (UVA doses of 1-8 J/cm2) in rat[3].
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