Ophiopogonin B
CAS No. : 38971-41-4
(Synonyms: OP-B)
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| Cat. No. : | HY-N1961 |
| M.Wt: | 722.90 |
| Formula: | C39H62O12 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ophiopogonin B (OP-B) induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1].
In Vitro:Ophiopogonin B (0, 5, 10 and 20 μM) suppresses the proliferation of HT-29 and HCT-116 cell lines through the G0/G1 phase cell cycle arrest[1].
Ophiopogonin B induces apoptosis by inhibiting the expression of Bax and cleaved caspase 3 and promoting the expression of Bcl-2. Treatment with Ophiopogonin B also increases the expression of Beclin 1 and the conversion of LC3I to LC3II with the activation of JNK/c-Jun signaling pathway[1].
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