IW927
CAS No. : 389142-48-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $390 | In-stock |
| 10mg | $625 | In-stock |
| 25mg | $1312 | In-stock |
| 50mg | $2100 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-118922 |
| M.Wt: | 441.57 |
| Formula: | C22H23N3O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
IW927 is a photochemically enhanced TNF-α-TNFR1 interaction inhibitor that blocks the binding of TNF-α to TNFRc1 with an IC50 value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity (Kd = 40-100 μM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40. IW927 disrupts TNFα-induced IκB phosphorylation with an IC50 value of 600 nM. IW927 can be used to develop light-independent inhibitors[1].
In Vitro:IW927 (1 μM in the light or 100 μM in the dark, 5 min) exhibits significant light dependence, forming irreversible covalent binding to TNFRc1 only under light conditions and only reversible binding under light-protected conditions[1].
IW927 (24 h) does not display any cytotoxicity at concentrations as high as 100 μM in Ramos cells[1].
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