Carbidopa (monohydrate)
CAS No. : 38821-49-7
(Synonyms: (S)-(-)-Carbidopa (monohydrate))
| Size | Price | Stock |
|---|---|---|
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| 250mg | $43 | In-stock |
| 500mg | $62 | In-stock |
| 1g | $88 | In-stock |
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| Cat. No. : | HY-B0311A |
| M.Wt: | 244.24 |
| Formula: | C10H16N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C) |
Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth[1][2].
In Vitro: Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191[1].
Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC50=29 μM)[3].
In Vivo: Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts[1].
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