Cucurbitacin D
CAS No. : 3877-86-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $300 | In-stock |
| 10mg | $500 | In-stock |
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| Cat. No. : | HY-N1986 |
| M.Wt: | 516.67 |
| Formula: | C30H44O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 110 mg/mL (ultrasonic) |
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects[1][2][3][4].
In Vitro:Cucurbitacin D (0.5 μg/mL, 24 h) combined with doxorubicin can induce apoptosis in MCF7/ADR cells and cause G2/M cell cycle arrest[1].
Cucurbitacin D (0.125-16 μg/mL, 24-72 h) significantly inhibits the growth of MCF7 and MCF7/ADR cells in a dose- and time-dependent manner[1].
Cucurbitacin D (0.5-2 μg/mL, 24 h) inhibits STAT3 signaling in MCF7/ADR cells and suppresses the NF-κB signaling pathway[1].
Cucurbitacin D enhances the production of IL-1β in LPS (HY-D1056) induced THP-1, PECs, BMDMs, and RAW264 cells[2].
In Vivo:Cucurbitacin D (1 mg/kg, intratumoral injection, three times a week for four weeks) inhibits tumor proliferation in mice[3].
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