8-Hydroxyguanosine
CAS No. : 3868-31-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $156 | In-stock |
| 25mg | $280 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $780 | In-stock |
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| Cat. No. : | HY-113262 |
| M.Wt: | 299.24 |
| Formula: | C10H13N5O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C) |
8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome[1][2][3][4].
In Vitro:8-Hydroxyguanosine (0.25 or 1.0 mM, 3 days) stimulates polyclonal immunoglobulin secretion and in the presence of antigen enhances the magnitude of the anti-TNP plaque-forming-cell antibody response to TNP-Ficoll [3].
In Vivo:8-Hydroxyguanosine (60 mg/kg, i.p., 4 h before LPS (1 mg/kg) injected) attenuates the LPS-induced increase in serum levels of TNF-α and IL-18 in LPS-treated mice[4].
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- 8-Hydroxyguanosine
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- HY-113262
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