Oxotremorine M (iodide)
CAS No. : 3854-04-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 50mg | $64 | In-stock |
| 100mg | $114 | In-stock |
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| Cat. No. : | HY-101372A |
| M.Wt: | 322.19 |
| Formula: | C11H19IN2O |
| Purity: | >98 % |
| Solubility: | H2O : 8.33 mg/mL (ultrasonic);DMSO : 125 mg/mL (ultrasonic) |
Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. Oxotremorine M iodide potentiates NMDA receptors by muscarinic receptor dependent and independent mechanisms[1].
In Vitro: Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence[2].
Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC50 of 0.22 μM. Oxotremorine M iodide has EC50s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively[3].
In Vivo: Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g[4].
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