UC-112
CAS No. : 383392-66-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $140 | In-stock |
| 10mg | $220 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1350 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-12842 |
| M.Wt: | 348.44 |
| Formula: | C22H24N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic) |
UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM). IC50 value: 0.7-3.4 uM (Cell assay) [1] Target: IAP inhibitor in vitro: UC-112 also potently inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO (MG-132) rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112 [1]. in vivo: As a single agent, UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked IAP and survivin levels in an A375 human melanoma xenograft model in vivo [1].
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