NSC668394
CAS No. : 382605-72-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $370 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $980 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-115492 |
| M.Wt: | 452.10 |
| Formula: | C17H12Br2N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a Kd of 12.59 μM. NSC668394 inhibit ezrin T567 phosphorylation caused by PKCΙ primarily via their binding to ezrin. NSC668394 can be used to prevent tumor metastasis[1][2][3].
In Vitro: NSC668394 (10 μM; pretreated for 15 min) inhibits ezrin T567 phosphorylation (IC50=8.1 μM) and actin binding in vitro[1].
NSC668394 (1-10 μM; 2-6 h) inhibits ezrin-mediated invasion by K7M2 osteosarcoma (OS) cells on the HUVEC monolayer[1].
NSC668394 (20 μM) causes significant decrease in growth in JM1 and JM2 rat hepatoma cell lines[2].
NSC668394 (10 μM) reduces cell motility phenotypes in zebrafish[1].
In Vivo: NSC668394 (0.226 mg/kg/day; i.p. 5-days a week) inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung[1].
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