Pyroxamide
CAS No. : 382180-17-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $94 | In-stock |
| 25mg | $198 | In-stock |
| 50mg | $341 | In-stock |
| 100mg | $594 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-13216 |
| M.Wt: | 265.31 |
| Formula: | C13H19N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia[1]. IC50 & Target: ID50: 100 nM[1] In Vitro: Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture[1]. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively[1].
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