Bacopaside II
CAS No. : 382146-66-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $380 | In-stock |
| 10mg | $680 | In-stock |
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| Cat. No. : | HY-N6016 |
| M.Wt: | 929.10 |
| Formula: | C47H76O18 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Bacopaside II, an extract from the medicinal herb Bacopa monnieri. Bacopaside II is the inhibitor for AQP1 that exhibits anti-angiogenesis activity. Bacopaside II exhibits cytotoxicity and induces apoptosis in cancer cells[1][2].
In Vitro:Bacopaside II (7.5-15 μM, 20 h) inhibits AQP1-mediated transport, affects cell volume and shape changes, thereby blocking cell migration and tube formation in cells 2H11, 3B11, and HUVEC[1].
Bacopaside II (0-30 μM, 72 h) inhibits the proliferation of cancer cells HT-29, SW480, SW620 and HCT116 with IC50s of 18.4 µM, 17.3 µM, 14.6 µM and 14.5 µM, respectively[2].
Bacopaside II (0-30 μM, 24 h) arrests cell cycle at G0/G1 phase (HT-29), or at the G2/M phase (SW480, SW620 and HCT116), and induces apoptosis[2].
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