7,8-Dihydroxyflavone
CAS No. : 38183-03-8
| Size | Price | Stock |
|---|---|---|
| 25mg | $60 | In-stock |
| 50mg | $88 | In-stock |
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| Cat. No. : | HY-W013372 |
| M.Wt: | 254.24 |
| Formula: | C15H10O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases[1]. IC50 & Target: TrkB[1] In Vitro: 7,8-Dihydroxyflavone (500 nM) protects the primary cortical neurons and locus coeruleus (LC) neurons from Aβ-induced toxicity and promotes dendritic growth and synaptogenesis[1]. In Vivo: 7,8-Dihydroxyflavone (5 mg/kg/day) prevents synaptic loss and memory deficits in a mouse model of Alzheimer’s Disease[1].
Administration of 7,8- dihydroxyflavone to mice activates TrkB in the brain, inhibits kainic acid-induced toxicity, decreases infarct volumes in stroke in a TrkBdependent manner, and is neuroprotective in an animal model of Parkinson disease[2].
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