Efipladib
CAS No. : 381683-94-9
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| 50mg | $4100 | Get quote |
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| Cat. No. : | HY-106253 |
| M.Wt: | 746.14 |
| Formula: | C40H35Cl3N2O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Efipladib is a potent, selective and orally active cPLA2α inhibitor with an IC50 of 0.04 μM and a Kd of 0.067 μM[1].
In Vitro: Efipladib (10-25 μM; 24-72 h) increases COX-1 and PGE2 levels in PC3 and LNCaP cells[3].
In Vivo: Efipladib (100 mg/kg; p.o.; BID for 31 days) reverses the severity in mouse collagen-induced arthritis (CIA) model[1].
Efipladib (100 mg/kg; p.o.; once) significantly inhibits the nociceptive response 1 h after administration in the rat Complete Freund’s Adjuvant (CFA) nociception model[2].
Efipladib is unable to cross the BBB to gain access to the central compartment[2].
Efipladib (100 nM; IT; 5 μL) reduces PGE2 levels in the cerebrospinal fluid in rats[2].
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