Oglufanide
CAS No. : 38101-59-6
(Synonyms: H-Glu-Trp-OH; L-Glutamyl-L-tryptophan)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $680 | In-stock |
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| Cat. No. : | HY-13718 |
| M.Wt: | 333.34 |
| Formula: | C16H19N3O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 15.5 mg/mL (ultrasonic;warming) |
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities[1][2][3].
In Vitro:Oglufanide (IM862) (1-1000 μg/mL) exhibits dose dependent inhibition of angiogenesis in the chorioallantoic membrane assay with complete inhibition of β-FGF and VEGF-induced angiogenesis[3].
Oglufanide (L-glu-L-trp) (0-1000 μg/mL; 5 days) has no effect on the viability of either the tumor cell lines or HUVECs[4].
In Vivo:Oglufanide (L-glu-L-trp) (1-100 mg/kg/day; s.c.; 10 days) has antitumor activity in immunocompetent and immunodeficient mice[4].
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