Bosutinib
CAS No. : 380843-75-4
(Synonyms: SKI-606)
| Size | Price | Stock |
|---|---|---|
| 5mg | $42 | In-stock |
| 10mg | $66 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $132 | In-stock |
| 100mg | $198 | In-stock |
| 200mg | $238 | In-stock |
| 250mg | $270 | In-stock |
| 500mg | $390 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-10158 |
| M.Wt: | 530.45 |
| Formula: | C26H29Cl2N5O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 46 mg/mL |
Bosutinib is an orally active Src/Abl tyrosine kinase inhibitor with IC50 of 1.2 nM and 1 nM, respectively[1]. IC50 & Target:IC50: 1.2 nM (Src), 1 nM (Abl)[1] In Vitro:Bosutinib (SKI-606) is an active inhibitor of Bcr-Abl in several chronic myelogenous leukemia cell lines, with IC50 values in the low nanomolar range[2]. In Vivo:Bosutinib (oral gavage; 75 mg/kg twice daily or 150 mg/kg once daily) has activity against human KU812 xenografts in nude mice. Bosutinib (150 mg/kg; once daily, 5 days weekly) has activity against syngeneic Bcr-Abl WT and mutant Ba/F3 xenografts[2].
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