SM-7368
CAS No. : 380623-76-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $40 | In-stock |
| 10mg | $60 | In-stock |
| 25mg | $133 | In-stock |
| 50mg | $200 | In-stock |
| 100mg | $300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-116626 |
| M.Wt: | 328.69 |
| Formula: | C10H5ClN4O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C) |
SM-7368 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation[1]. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis [2].
In Vitro: SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines[1].
SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line[2].
SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation[2].
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