SRPIN803
CAS No. : 380572-02-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $275 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $880 | In-stock |
| 100mg | $1410 | In-stock |
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| Cat. No. : | HY-114653 |
| M.Wt: | 370.31 |
| Formula: | C14H9F3N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C) |
SRPIN803 is a potent CK2 and SRPK1 dual inhibitor, with IC50s of 203 nM and 2.4 μM, respectively. SRPIN803 exhibits antiangiogenic activity. SRPIN803 can be used for the research of age-related macular degeneration[1][2][3].
In Vitro:SRPIN803 inhibits the activity of SRPK1 toward LBRNt (62-92), with an IC50 of 7.5 μM, while the c(RGDyK)-conjugated compounds completely abolishes its inhibitory activity[2].
SRPIN803 has slightly cytostatic activity against Hcc827, PC3, and U87 (GI50=80-98 μM)[2].
In Vivo:SRPIN803 (topical administration of eye ointment) significantly inhibits choroidal neovascularization in a mouse model of age-related macular degeneration[2].
SRPIN803 (100 μM; 72 h) inhibit zebrafish angiogenesis[2].
SRPIN803 (4.6 nL of 10 μM; microinjection; 72 h) block angiogenesis in the developing embryo at the one-cell stage of zebrafish[2].
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