Nitrobenzylthioinosine
CAS No. : 38048-32-7
(Synonyms: NBMPR)
| Size | Price | Stock |
|---|---|---|
| 10mg | $50 | In-stock |
| 25mg | $100 | In-stock |
| 50mg | $165 | In-stock |
| 100mg | $270 | In-stock |
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| Cat. No. : | HY-W010936 |
| M.Wt: | 419.41 |
| Formula: | C17H17N5O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Nitrobenzylthioinosine is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier[1][2][3].
IC50 & Target:ENT1 transporter[1]
In Vitro:Nitrobenzylthioinosine (0-25 μM) can inhibit uridine uptake by HeLa cells[4].
Nitrobenzylthioinosine (10 μM, 72 h) combines with N-Phosphonacetyl-L-aspartic acid (PALA) can inhibit the viability of B16 melanoma cells[5].
In Vivo:Nitrobenzylthioinosine (50, 100 mg/kg, intraperitoneally injected, 4 times a day) combines with N-Phosphonacetyl-L-aspartic acid (PALA) can inhibit the growth of B16 melanoma[5].
Nitrobenzylthioinosine (50 nM, intraventricular injection) can protect rat CA1 pyramidal neurons from ischemic death[6].
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