Melflufen
CAS No. : 380449-51-4
(Synonyms: Melphalan flufenamide)
| Size | Price | Stock |
|---|---|---|
| 1mg | $290 | In-stock |
| 5mg | $720 | In-stock |
| 10mg | $980 | In-stock |
| 25mg | $1520 | In-stock |
| 50mg | $1980 | In-stock |
| 100mg | $2500 | In-stock |
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| Cat. No. : | HY-105019 |
| M.Wt: | 498.42 |
| Formula: | C24H30Cl2FN3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Melflufen (Melphalan flufenamide), a dipeptide prodrug of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells[1][2][3].
In Vitro: Melflufen (Melphalan flufenamide) (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner[1].
Melflufen induces apoptosis in MM.1S cells[1].
Melphalan also is a potent activator of exosome secretion[3].
In Vivo: Melflufen (Melphalan flufenamide) (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model[1].
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