Cimifugin
CAS No. : 37921-38-3
(Synonyms: Cimitin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $25 | In-stock |
| 5mg | $50 | In-stock |
| 10mg | $70 | In-stock |
| 25mg | $110 | In-stock |
| 50mg | $160 | In-stock |
| 100mg | $250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0634 |
| M.Wt: | 306.31 |
| Formula: | C16H18O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 33.33 mg/mL (ultrasonic) |
Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions[1]. Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS[2].
In Vitro: The effect of Cimifugin (Cimitin) on TSLP decreases significantly when expression of CLDN1 is interfered with siRNA and this implied Cimifugin inhibits initiative cytokines through restoring TJs[1].
In Vivo: Cimifugin (Cimitin; 12.5 or 50 mg/kg/day; intragastrically; 2 days) significantly inhibits TSLP and IL-33 in the initial stage of Mice are sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. Simultaneously, Cimifugin reduces the separated gap among the epithelial cells and increased the expression of TJs[1].
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