Jolkinolide A
CAS No. : 37905-07-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | Get quote |
| 5mg | $140 | Get quote |
| 10mg | $230 | Get quote |
| 25mg | $460 | Get quote |
| 50mg | $690 | Get quote |
| 100 mg | Get quote | |
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| Cat. No. : | HY-119767 |
| M.Wt: | 314.42 |
| Formula: | C20H26O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1].
IC50 & Target:VEGF[1]
In Vitro:Jolkinolide A (20-100 μg/mL; 24 h) increases the protein level of caspase-9 in A549 cells[1].
Jolkinolide A (40-80 μg/mL; 24 h) reduces the expression of Akt-STAT3-mTOR proteins in A549 cells[1].
Jolkinolide A (20-100 μg/mL; 24 h) inhibits human umbilical vein endothelial cells (HUVECs) proliferation and migration, and promotes apoptosis[1].
In Vivo:Jolkinolide A (40 mg/kg; i.p.; once every 3 days, for 2 months) inhibits the expression of the VEGF protein in A549 cell xenograft tumor model in mouse[1].
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