Nepodin


CAS No. : 3785-24-8

(Synonyms: Musizin)

3785-24-8
Price and Availability of CAS No. : 3785-24-8
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Cat. No. : HY-N5018
M.Wt: 216.23
Formula: C13H12O3
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 3785-24-8 :

Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities. In Vitro: Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].
In Vivo: Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2].

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