Zaprinast
CAS No. : 37762-06-4
(Synonyms: M&B 22948)
| Size | Price | Stock |
|---|---|---|
| 5mg | $25 | In-stock |
| 10mg | $42 | In-stock |
| 25mg | $88 | In-stock |
| 50mg | $133 | In-stock |
| 100mg | $200 | In-stock |
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| Cat. No. : | HY-B1816 |
| M.Wt: | 271.27 |
| Formula: | C13H13N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5). Zaprinast causes a significant increase in cGMP levels in myocytes. Zaprinast is a G protein-coupled receptor 35 (GPR35) agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects[1][2][3].
IC50 & Target:PDE[1], GPR35[2]
In Vitro:Zaprinast (0.1, 0.3, 1, 3, 10, 30 μM) induces intracellular calcium mobilization in the transfectant coexpressing FLAG-hGPR35 and the four exogenous Gα proteins in a concentration-dependent manner in HEK293 cells[2].
Zaprinast (100 μM; 5 min) can promote phosphorylation of five distinct amino acids in the C-terminal tail of human GPR35a in HEK293T cells[4].
In Vivo:Zaprinast (3 and 10 mg/kg; i.p.) enhances spatial memory in elevated plus maze (EPM) and diminishes exploratory activity in the Hughes box test[5].
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