CCPA
CAS No. : 37739-05-2
(Synonyms: 2-Chloro-N6-cyclopentyladenosine)
| Size | Price | Stock |
|---|---|---|
| 25mg | $89 | In-stock |
| 50mg | $150 | In-stock |
| 100mg | $255 | In-stock |
| 250mg | $484 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-103185 |
| M.Wt: | 369.80 |
| Formula: | C15H20ClN5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA inhibits adenylate cyclase with an IC50 of 33 nM. CCPA exhibits anti-seizure and cardiacprotective activity. CCPA can be used for the research of seizure and myocardial infarction[1][2][3].
In Vitro:CCPA potently binds to rat brain membrane A1 adenosine receptors with a Ki of 0.4 nM, demonstrating high A1 selectivity (Ki of 3900 nM for A2)[1].
CCPA acts as a full A1 adenosine receptor agonist to inhibit rat fat cell membrane adenylate cyclase with an IC50 of 33 nM, and shows an IC50 of 3500 nM for A2[1].
In Vivo:CCPA (0.25-0.5 mg/kg; i,p,; single dose) increases the electroconvulsive threshold in a mouse model of seizures induced by maximal electroshock (MES)[2].
CCPA (0.125 mg/kg; i.v.; 30 min before induction) reduces infarct size in a rabbit model of coronary artery occlusion-induced myocardial infarction[3].
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