Clofoctol
CAS No. : 37693-01-9
| Size | Price | Stock |
|---|---|---|
| 100mg | $90 | In-stock |
| 500mg | $280 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-B1150 |
| M.Wt: | 365.34 |
| Formula: | C21H26Cl2O |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : 100 mg/mL (ultrasonic) |
Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency[1][2][3].
In Vitro: Clofoctol (0-100 μM; 72 h) inhibits prostate cancer cell growth[2].
Clofoctol (0-20 μM; 24 h) arrests cell cycle at G1 phase[2].
Clofoctol (0-30 μM; 0-24 h) induces ER stress and activates UPR pathways[2].
Clofoctol (0-40 μM; 24 h) inhibits translation[2].
Clofoctol (0-100 μM; 24 h) shows antiviral effect against SARS-CoV-2 with IC50s of 9.3 μM and 11.59 μM in Vero-81 and Vero-81-TMPRSS2 cells, respectively[3].
In Vivo: Clofoctol (175 mg/kg; i.p.; daily for 37 days) is capable of blocking tumour growth without apparent toxicity in a mouse model of human prostate cancer xenograft[2].
Clofoctol (62.5 mg/kg; i.p.; twice) inhibits SARS-CoV-2 replication and lowers inflammation in lungs in mice with SARS-CoV-2 infection[3].
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