BVT-14225
CAS No. : 376638-65-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $57 | In-stock |
| 5mg | $120 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $330 | In-stock |
| 50mg | $540 | In-stock |
| 100mg | $780 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18055 |
| M.Wt: | 401.93 |
| Formula: | C16H20ClN3O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52 nM. IC50 & Target:IC50: 52 nM (11β-HSD1)[1] In Vitro: Selective inhibition of 11β-HSD1 decreases blood glucose concentrations in hyperglycaemic mice. Selective inhibitors of 11β-HSD1 have considerable potential as treatments for a number of diseases of great unmet medical need such as type 2 diabetes, obesity and metabolic syndrome, a multifactorial disorder. BVT-14225 shows high activity in the enzyme assay with 90% inhibition at 10 μM. It has an IC50 for 11β-HSD1 on a human enzyme assay of 52 nM[2].
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