ZQ-16


CAS No. : 376616-73-8

376616-73-8
Price and Availability of CAS No. : 376616-73-8
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5mg $90 In-stock
10mg $145 In-stock
25mg $270 In-stock
50mg $435 In-stock
100mg $700 In-stock
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Cat. No. : HY-124571
M.Wt: 228.31
Formula: C10H16N2O2S
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 376616-73-8 :

ZQ-16 is a potent and selective GPR84 agonist with an EC50 value of 0.213 μM. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120[1]. In Vitro:ZQ-16 induces calcium response in a dose-dependent manner, with an EC50 value of 0.213 μM[1].
ZQ-16 also induces dose-dependent reduction of Forskolin-stimulated cAMP accumulation in HEK293 cells expressing GPR84 with an EC50 value of 0.134 μM[1].
ZQ-16 (10 μM; 5 min) also induces phosphorylation of ERK1/2 in GPR84-expressing HEK293 cells[1].
ZQ-16 induces GPR84 desensitization, internalization, and β-arrestin2 recruitment. ZQ-16 induced a dose-dependent recruitment of β-Arrestin2 towards GPR84 in HEK293 cells expressing both proteins with an EC50 value of 0.597 μM[1].

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