BRD7389
CAS No. : 376382-11-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $310 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $670 | In-stock |
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| Cat. No. : | HY-12185 |
| M.Wt: | 366.41 |
| Formula: | C24H18N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C) |
BRD7389 is a specific RSK family kinase inhibitor with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells[1].
In Vitro: BRD7389 (0.425-6.8 μM) induces insulin expression in mouse α-cells after 3 days treatment. BRD7389 induces a dose-dependent up-regulation of insulin (Ins2) mRNA, peaking at 0.85 μM; 5 days treatment with BRD7389 results in greater induction of insulin gene expression, about 50-fold at 0.85 μM[1].
BRD7389 (0.85-6.8μM) significantly up-regulates Pdx1 mRNA expression in mouse α-cell line[1].
BRD7389 also increases β-cell-specific gene expression in primary human islet cells[1].
BRD7389 (1 μM; added 30 min prior to Carbachol treatment 48 h) fully abolishes carbachols timulated cell proliferation, but has little effect on the basal level of proliferation[2].
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