Amikacin
CAS No. : 37517-28-5
(Synonyms: BAY 41-6551)
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| Cat. No. : | HY-B0509A |
| M.Wt: | 585.60 |
| Formula: | C22H43N5O13 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Amikacin (BAY 41-6551) is a semisynthetic kanamycin analog that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains. Significant inhibitory effect. Amikacin is ototoxic and nephrotoxic. Amikacin can be used in bacteriostatic, anti-cancer and analgesic studies[1][2][3][4][5].
In Vitro:Amikacin (30 µg, 0-24 h) has antibacterial activity, with a MIC50 value of 512 µg/mL against clinically isolated E. coli, and has a synergistic effect with imipenem (HY-B1369A), and the antibacterial effect is better when used in combination[1].
Amikacin (250 µg/mL, 0-24 h) inhibits the migration and invasion of human breast cancer cell line MDA-MB-231 cells by up-regulating the expression of TXNIP, indicating its anti-tumor potential[2].
In Vivo:Amikacin (single 30 mg/kg, s.c. or i.p.) has an analgesic effect in mice and has a synergistic effect when combined with morphine, but the analgesic effect of Amikacin can be reversed by Naloxone (HY-17417A)[3].
Amikacin (500 mg/kg/day for 8 days, s.c.) damages calpain activity in rat cochlea, promotes the degradation of sensory cells and neurons, and then leads to ototoxicity[4].
Amikacin (100 and 500 mg/kg/day for 10 days, s.c.) is nephrotoxic and its continued accumulation in rats can lead to kidney damage[5].
Pharmacokinetic Analysis in SD rats[5]
| Route | Dose (mg/kg) | Ka (h-1) | Ke1 (h-1) | t1/2 (h) | V (liter/kg) | AUC0-∞ (mg·h/mL) |
| s.c. | 100 | 1.20 | 6.77 | 0.10 | 0.28 | 53.0 |
| s.c. | 500 | 1.40 | 1.39 | 0.50 | 0.55 | 649.7 |