Perfluoroenanthic acid

Perfluoroenanthic acid (Perfluoroheptanoic acid) is a kind of perfluoroalkyl carboxylic acid organic pollutant. Perfluoroenanthic acid has environmental persistence and bioaccumulation, and exposure can occur via oral, dermal and other routes. Perfluoroenanthic acid exhibits reproductive toxicity, neurotoxicity, hepatotoxicity, immunotoxicity and endocrine-disrupting effects. Perfluoroenanthic acid exerts definite adverse effects on development, spermatogenesis, neuronal activity and liver tissue^[1][2][3]. In Vivo:Perfluoroenanthic acid (0.0015-0.15 mg/kg bw/d; oral gavage; daily; 16 days) induces reproductive toxicity in male offspring of C57BL/6 mice^[1].
Perfluoroenanthic acid (1.25-5% (v/v); percutaneous administration; once daily; for 28 consecutive days) induces systemic toxicity in female B₆C₃F₁ mice in a subchronic 28-day skin exposure model, including increased liver weight, altered immune cell phenotypes, hepatocyte hypertrophy, and dysregulated gene expression associated with the PPAR pathway^[3].