ASP2535
CAS No. : 374886-51-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $575 | In-stock |
| 10mg | $980 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-110176 |
| M.Wt: | 382.42 |
| Formula: | C22H18N6O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ASP2535 is a potent, orally bioavailable, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor. ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1].
IC50 & Target: GlyT1[1]
In Vitro: ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro[1].
In Vivo: ASP2535 (0.3-3 mg/kg; p.o) attenuates working memory deficit in MK-801-treated mice and visual learning deficit in neonatally phencyclidine (PCP)-treated mice[1].
ASP2535 (1-3 mg/kg, p.o.) also improves the PCP-induced deficit in prepulse inhibition in rats[1].
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- Cat. No.:
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