Istaroxime (hydrochloride)
CAS No. : 374559-48-5
(Synonyms: PST2744 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $550 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1425 | In-stock |
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| Cat. No. : | HY-15718A |
| M.Wt: | 396.95 |
| Formula: | C21H33ClN2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 45 mg/mL;H2O : 25 mg/mL (ultrasonic) |
Istaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator. IC50 & Target: IC50: 0.11 μM (Na+,K+-ATPase)[1] In Vitro: Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na+,K+-ATPase[2]. Istaroxime (PST2744) inhibits the Na+/K+-ATPase activity from dog kidney with an IC50 value of 0.43 ± 0.15 μM. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744[3]. In Vivo: Istaroxime (PST2744) induces a progressive increase in +dP/dtmax throughout the infusion that reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg[3].
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