Moroxydine
CAS No. : 3731-59-7
(Synonyms: ABOB)
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| Cat. No. : | HY-W016937 |
| M.Wt: | 171.20 |
| Formula: | C6H13N5O |
| Purity: | >98 % |
| Solubility: |
Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels[1][2][3]. In Vitro:
Moroxydine hydrochloride (HY-B0420A) used in papers
Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against grass carp reovirus (GCRV) in Ctenopharyngodon idella kidney (CIK) cells (TC50 = 1246.0 μg/mL, SC = 218.5 μg/mL) and grass carp ovary (GCO) cells (TC50 = 117.2 μg/mL, SC = 140.9 μg/mL)[1][2].
Moroxydine (1-100 μg/mL, 24-96 h) shows protective effects against giant salamander iridovirus (GSIV) in epithelioma papulosum cyprinid (EPC) cells, with a TC50 of 1486.3 μg/mL and a safe concentration (SC) of 209.7 μg/mL[2].
Moroxydine (40 μg/mL, 48-96 h) blocks the virus-induced CPE and cell death within 96 h and maintained the normal structure and nucleocapsids[1].
Moroxydine (40 μg/mL, 48-96 h) significantly decreases the apoptosis in CIK cells (GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].
Moroxydine (12-48 h) significantly inhibits the caspase 3 activity, Bax expression and down-regulates Bcl-2 at 48 h in CIK cells[1].
Moroxydine (20 μg/mL, 12-72 h) shows time-dependent suppression of viral gene expression in CIK cells(GCRV), GCO cells (GCRV) and EPC cells (GSIV)[1][2].
Moroxydine (20 μg/mL, 72 h) arrests cell cycle in the period of G1/S and G2/M of CIK cells[3].
Moroxydine (3-7 days) inhibits the GCRV-induced upregulation of immune genes (IL-1β, IFN-I, TNF-α) in the kidney, liver, muscle and gill[3].
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