Validamycin A
CAS No. : 37248-47-8
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| Cat. No. : | HY-B0856 |
| M.Wt: | 497.49 |
| Formula: | C20H35NO13 |
| Purity: | >98 % |
| Solubility: | H2O : 125 mg/mL (ultrasonic) |
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1?μg/mL[1]. Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM[2]. Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM[3].
IC50 & Target:Antibiotic[1], IC50: 72 μM (trehalase)[2], Ki: 5.893 mM (tyrosinase)[3]
In Vitro: Validamycin A (0.5-1 μg/mL; 18 hours) inhibits the growth of A. flavus and delayed conidial germination[1].
Validamycin A shows no cytotoxicity to human bronchial epithelial cells[1].
Validamycin A directly binds to several residues in the active site of tyrosinase, including HIS85, HIS244, GLU256, HIS259 and ASN260[1].
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