Namitecan
CAS No. : 372105-27-6
(Synonyms: ST-1968)
| Size | Price | Stock |
|---|---|---|
| 5mg | $500 | In-stock |
| 10mg | $850 | In-stock |
| 50mg | $2550 | In-stock |
| 100mg | $4080 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-14821 |
| M.Wt: | 434.44 |
| Formula: | C23H22N4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Namitecan is a potent topoisomerase I inhibitor, with antitumor property. In Vitro: Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines[1]. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC50 of 0.21 and 0.29 μM[2]. In Vivo: Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number[1]. ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor[2].
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