A-317567
CAS No. : 371217-32-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $450 | In-stock |
| 10mg | $800 | In-stock |
| 25mg | $1650 | In-stock |
| 50mg | $2550 | In-stock |
| 100mg | $3800 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-122135 |
| M.Wt: | 397.56 |
| Formula: | C27H31N3 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
A-317567 is a potent acid-sensing ion channel 3 (ASIC-3) inhibitor with an IC50 of 1.025 μM. A-317567 has antidepressant and antinociception effects[1][2]. IC50 & Target:IC50: 1.025 μM (Acid-sensing ion channel 3 (ASIC-3))[1] In Vitro:In acutely dissociated adult rat dorsal root ganglion (DRG) neurons, A-317567 produces concentration-dependent inhibition of all pH 4.5-evoked ASIC currents with an IC50 ranging between 2 and 30 μM. A-317567 equipotently blocks the sustained phase of ASIC3-like current, a biphasic current akin to cloned ASIC3, which is predominant in DRG[2]. In Vivo:A-317567 (1-100 μmol/kg; i.p; once) is fully analgesic effects in the CFA model (ED50 of 17 μmol/kg). There is no significant effect of A-317567 on the withdrawal latency of the contralateral paw under these conditions[2].
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