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TMPyP4 tosylate


CAS No. : 36951-72-1

(Synonyms: TMP 1363)

36951-72-1
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Cat. No. : HY-108477
M.Wt: 1363.60
Formula: C72H66N8O12S4
Purity: >98 %
Solubility: DMSO : 10 mg/mL (ultrasonic);H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Introduction of 36951-72-1 :

TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2[1][2][3][6]. In Vitro:TMPyP4 tosylate (50  µM, 96 h) inhibits telomerase activity in telomerase positive HOS cells[2].
TMPyP4 tosylate (50  µM, 48 or 96 h) inhibits the growth of HOS cells[2].
TMPyP4 tosylate (50  µM, 96 h) induces cell apoptosis in HOS, Saos-2, MG-63, and U2OS cell lines[2].
TMPyP4 tosylate (100  µM, 24 or 48 h) increases cell cycle regulatory proteins and MAPKs in K562 cells[4].
In Vivo:TMPyP4 tosylate (10 and 20 mg/kg, i.p., two times weekly) inhibits tumor growth in MX-1 tumor model[5].
TMPyP4 tosylate (15 mg/kg or 30 mg/kg, i.n.) decreases the mean viral loads in SARS-CoV-2-infected hamster[6].
TMPyP4 tosylate (30 mg/kg, i.n., hamsters) shows a Cmax of 17.88 μg/mL at 1 h, and a half-life (T1/2) of 6.36 h[6].

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