Oroxylin A-7-O-glucuronide
CAS No. : 36948-76-2
(Synonyms: Oroxyloside; Oroxylin A-7-O-β-D-glucuronide)
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| Cat. No. : | HY-N2481 |
| M.Wt: | 460.39 |
| Formula: | C22H20O11 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560). Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities[1][2][3][4][5][6].
In Vitro:Oroxylin A-7-O-glucuronide (40-160 μM; 24 h) inhibits the viability and invasion ability of EA.hy926 cells[1].
Oroxylin A-7-O-glucuronide (5-100 μM; 24 h) significantly suppresses the glioma cell proliferation in a dose-dependent manner in U87-MG, U251-MG, U138-MG and SHG44 cells, with IC50 values of 36.87, 52.36, 59.67 and 56.39 μM, respectively[2].
Oroxylin A-7-O-glucuronide (100 μM; 24 h) reduces APAP (HY-66005)-induced apoptosis and necroptosis in L02 and AML12 cells by inhibiting JNK pathway[3].
Oroxylin A-7-O-glucuronide (2-100 μM; 24 h) decreases LPS-induced pro-inflammatory cytokines in RAW264.7 and BMDM via PPARγ-mediated NF-κB inhibition[4].
Oroxylin A-7-O-glucuronide (50 μM) reduces H2O2-induced IL-6 production in L02 and LX2 cells through autophagy activation[5].
In Vivo:Oroxylin A-7-O-glucuronide (40-80 mg/kg; i.v.; every two days) inhibits angiogenesis in Matrigel plug assay and reduces growth of A549 xenografted tumors in nude mice with low toxicity[1].
Oroxylin A-7-O-glucuronide (10-40 mg/kg; p.o.; daily; 4 weeks) suppresses U87-MG xenograft tumor growth in athymic nude mice without affecting body weight and organ function [2].
Oroxylin A-7-O-glucuronide (100 mg/kg; i.g.) ameliorates APAP (HY-66005)-induced hepatotoxicity in C57BL/6 mice by reducing serum ALT/AST and liver inflammation[3].
Oroxylin A-7-O-glucuronide (20-80 mg/kg; p.o.; 10 days) alleviates DSS-induced colitis in C57BL/6 mice by reducing colon damage and pro-inflammatory cytokines [4].
Oroxylin A-7-O-glucuronide (20-80 mg/kg; i.g.; every other day) inhibits CCl4-induced liver fibrosis and DEN (HY-N7434) + CCl4 (HY-Y0298)-induced hepatocarcinogenesis in C57BL/6 and Atg5Hep-/- mice[5].
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