Icilin
CAS No. : 36945-98-9
(Synonyms: AG-3-5)
| Size | Price | Stock |
|---|---|---|
| 5mg | $41 | In-stock |
| 10mg | $66 | In-stock |
| 50mg | $242 | In-stock |
| 100mg | $418 | In-stock |
| 500mg | $1265 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-11062 |
| M.Wt: | 311.29 |
| Formula: | C16H13N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 54 mg/mL |
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a "super-cooling agent" [1][2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response[3]. In Vitro:Icilin-evoked TRPM8 currents show variable activation kinetics and Ca2+ dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization[1]. In Vivo:Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin (3 mg/kg; s.c.) induces "Wet dog shake" in mice[2].
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