MPP+ (iodide)
CAS No. : 36913-39-0
| Size | Price | Stock |
|---|---|---|
| 50mg | $48 | In-stock |
| 100mg | $82 | In-stock |
| 250mg | $139 | In-stock |
| 1g | $367 | In-stock |
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| 10 g | Get quote | |
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| Cat. No. : | HY-W008719 |
| M.Wt: | 297.14 |
| Formula: | C12H12IN |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic) |
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
In Vitro: MPP+ (1-3 mM; 24 hours) remarkably decreases the viability of cells[1].
MPP+ also inhibits the activity of nicotinamide adenosine dinucleotide (NADH)-linked respiration in mitochondrial preparations and impairs aerobic glycolysis, leading to the present belief that the inhibition of NADH-linked cell respiration may constitute the final molecular mechanism of MPP+ neurotoxicity[3].
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