LS-104
CAS No. : 368836-72-0
(Synonyms: Tyrene CR-4)
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| Cat. No. : | HY-118084 |
| M.Wt: | 320.34 |
| Formula: | C19H16N2O3 |
| Purity: | >98 % |
| Solubility: |
LS-104 (Tyrene CR-4) is a non-ATP-competitive kinase inhibitor against JAK2, Bcr-Abl and FLT3. LS-104 potently induces apoptosis in JAK2V617F-positive cells and inhibits JAK2 autophosphorylation and downstream signal transduction. LS-104 also inhibits proliferation and induces potent cytotoxic effects in FLT3 expressing leukemic cells. LS-104 is a hydroxystyryl-acrylonitrile compound, which is promising for research of myeloproliferative disorders and refractory/relapsed hematologic malignancies[1][2].
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